2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140033
    Propargyl-PEG3-amine 932741-19-0 98.0%
    Propargyl-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG3-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-amine
  • HY-140888
    Biotin-PEG2-NHS ester 596820-83-6
    Biotin-PEG2-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG2-NHS ester
  • HY-75005
    1-Boc-4-carboxymethyl piperazine 156478-71-6
    1-Boc-4-carboxymethyl piperazine is a PROTAC linker. 1-Boc-4-carboxymethyl piperazine can be used in the synthesis of PROTACs (e.g. PROTAC IRAK4 degrader-12 (HY-168586)).
    1-Boc-4-carboxymethyl piperazine
  • HY-133174
    Biotin-PEG5-azide 1163732-89-5
    Biotin-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Biotin-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG5-azide
  • HY-140691
    mPEG10000-Mal 99.89%
    mPEG10000-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    mPEG10000-Mal
  • HY-W004945
    3,6-Dioxaoctanedioic acid 23243-68-7 98.0%
    36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    3,6-Dioxaoctanedioic acid
  • HY-140456
    Azido-PEG12-acid 2152679-71-3 99.81%
    Azido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG12-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG12-acid
  • HY-W021909
    tert-Butyl 3-(bromomethyl)azetidine-1-carboxylate 253176-93-1 98.67%
    tert-Butyl 3-(bromomethyl)azetidine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
    tert-Butyl 3-(bromomethyl)azetidine-1-carboxylate
  • HY-W047688
    tert-Butyl (10-aminodecyl)carbamate 216961-61-4
    tert-Butyl (10-aminodecyl) carbamate (1-Boc-1,10-diaminodecane) is a synthetic intermediate that serves as a PROTAC linker in PROTAC synthesis and other conjugation applications. tert-Butyl (10-aminodecyl) carbamate is an alkane chain with a terminal amine and a Boc-protected amino group. The amine group can react with carboxylic acids, active NHS esters, carbonyl groups (ketones, aldehydes), etc. The Boc group can be deprotected under mild acidic conditions to form a free amine.
    tert-Butyl (10-aminodecyl)carbamate
  • HY-W158606
    2-[4-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-1-yl]acetic acid 221352-82-5 99.82%
    2-[4-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-1-yl]acetic acid is a PROTAC linker that can be used in the synthesis of PROTACs.
    2-[4-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-1-yl]acetic acid
  • HY-33796
    1-Boc-4-bromomethylpiperidine 158407-04-6 99.45%
    1-Boc-4-bromomethylpiperidine is a PROTAC linker that can be used in the synthesis of PROTACs.
    1-Boc-4-bromomethylpiperidine
  • HY-W059721
    3-(tert-Butoxycarbonyl)-3-azaspiro[5.5]undecane-9-carboxylic acid 170228-81-6
    3-(tert-Butoxycarbonyl)-3-azaspiro[5.5]undecane-9-carboxylic acid is a PROTAC linker that can be used in the synthesis of PROTACs.
    3-(tert-Butoxycarbonyl)-3-azaspiro[5.5]undecane-9-carboxylic acid
  • HY-W033978
    14-Bromotetradecan-1-ol 72995-94-9 98.06%
    14-Bromotetradecan-1-ol is a PROTAC linker that can be used in the synthesis of PROTACs.
    14-Bromotetradecan-1-ol
  • HY-W088729
    8-(tert-Butoxy)-8-oxooctanoic acid 234081-94-8 99.72%
    8-(tert-Butoxy)-8-oxooctanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs.
    8-(tert-Butoxy)-8-oxooctanoic acid
  • HY-Y0195
    Methyl 3-bromopropanoate 3395-91-3
    Methyl 3-bromopropanoate is a PROTAC linker that can be used in the synthesis of PROTACs.
    Methyl 3-bromopropanoate
  • HY-140963
    Mal-PEG12-NHS ester 2669737-09-9
    Mal-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG12-NHS ester
  • HY-W044155
    Azido-PEG2-azide 59559-06-7 98.11%
    Azido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-azide
  • HY-141106
    m-PEG12-NHS ester 2207596-93-6 ≥98.0%
    m-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG12-NHS ester
  • HY-126949
    Aminooxy-PEG3-azide 1306615-51-9 98.0%
    Aminooxy-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-C2-PEG3-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Aminooxy-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Aminooxy-PEG3-azide
  • HY-141373
    Bromo-PEG3-bromide 31255-26-2 98.77%
    Bromo-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG3-bromide
PROTAC Linkers Isoform Comparison

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